Sodium ethanemonothiophosphonate. A weak antidote to mustard gas

TRANSIENT DECREASED SERUM TESTOSTERONE AFTER EXPOSURE TO MUSTARD GAS

The effects of exposure to chemical weapons containing sulfur mustards on the serum levels of total and free testosterone. gonadotropins and prolactin was investigated in young Iranian men. In the first five weeks after injury both serum total and free testosterone were significantly decreased as compared to control values. Three of 13 men had total testosterone below 300 ng/dL and two of ...

Poisoning by "Mustard" Gas

Therapeutic options to treat mustard gas poisoning – Review

Among the blistering (vesicant) chemical warfare agents (CWA), sulfur mustard is the most important since it is known as the “King of chemical warfare agents”. The use of sulfur mustard has caused serious damages in several organs, especially the eyes, skin, respiratory, central and peripheral nervous systems after short and long term exposure, incapacitating and even killing people and troops....

Translational Antidote Research: A Bedside to Bench Tale

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...

Mustard Gas Induced Ocular Injuries

1 Mustard gas is a lipophilic, highly cytotoxic agent that rapidly penetrates tissue, and the eye is one of the organs mostly affected,[1] but skin, respiratory, gastrointestinal, and renal systems as well as the bone marrow may also be affected.[2] Mustard gas related ocular injuries can be divided into immediate, chronic, and delayed‐onset phases. Acute manifestations of varying degrees, incl...